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KMID : 0602620020080030317
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Korean Journal of Hepatology
2002 Volume.8 No. 3 p.317 ~ p.320
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A Case of Acute Cholestatic Hepatitis Associated with Orlistat
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김도현/Doh Hyun Kim
이은희/황재철/정재학/김도현/정재연/김원석/조성원/김영배*/Eun Hee Lee/Jae Chul Hwang/Jai Hak Jeung/Do Hyun Kim/Jae Youn Cheong/Sung Won Cho/Young Bae Kim*
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Abstract
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Orlistat(Xenical®, Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute
hepatic
failure leading to liver transplantation in a young women with moderate obesity treated with orlistat. We report a case of acute cholestatic hepatitis in a young woman with moderate obesity treated with orlistat: a 33-year-old female admitted for
the
evaluation of jaundice. Abdominal ultrasonography, ERCP, routine chemistry, viral markers, and a fine needle biopsy of liver were performed. Microscopic findings of the liver biopsy specimen were compatible with acute cholestatic hepatitis. After
steroid therapy, liver function was improved.
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